Short-rib polydactyly
Definition
Short-rib polydactyly (SRP) syndromes are a group of skeletal dysplasias consisting of short ribs, short limbs, extra fingers or toes, and various internal organ abnormalities present at birth. There are four types of SRP and all are fatal shortly after birth due to underdevelopment of the lungs.
Description
In 1972, R. M. Saldino and C. D. Noonan first described two siblings with a dwarfism syndrome and symptoms of extremely shortened limbs, short ribs, small chest, abnormal bone formation, extra fingers, and internal organ damage. Since then, three additional SRP subtypes have been identified, all named after those who first described them. The subtypes are: SRP type I (Saldino-Noonan), SRP type II (Majewski), SRP type III (Verma-Namauf), and SRP type IV (Beemer-Langer). While...
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