Definition

Larsen syndrome is an inherited condition characterized by congenital dislocation of multiple body joints along with other unusual features of the face, hands, and bones.

Description

This condition was first described in 1950 by Larsen, Schottstaedt, and Bost, who compiled information on six people with sporadic cases of Larsen syndrome.

Larsen syndrome has been called both a skeletal dysplasia (a condition caused by abnormalities of bone structure), and a hypermobility syndrome (a condition involving abnormally loose joints). It is most likely caused by inherited abnormalities of connective tissue that affect both bone and joint structure.

Present at birth are multiple dislocations of the elbows, hips, and most commonly the knees. Persons with Larsen syndrome have...