Definition

Hereditary spastic paraplegia (HSP) is a varied group of disorders, all primarily involving subtly progressing lower extremity muscle weakness and spasticity, or increased muscle reflexes.

Description

There are two primary groups of HSP, known as "uncomplicated" or "pure" HSP and "complicated" HSP. HSP is considered "uncomplicated" or "pure" if the neurological problems only include progressive lower extremity muscle weakness and spasticity, urinary bladder disturbances, a decreased ability to sense vibrations in the lower extremities, and a decreased ability to sense the position of the joints.

HSP is "complicated" if other complex problems are present such as seizures, dementia, loss of muscle...