Harlequin fetus
Definition
The term harlequin fetus is used to describe an extremely severe form of skin disease in which affected infants have thick, plate-like scales all over their bodies. This abnormality is present from birth. It leads to disfiguration of the facial features and limited movement of the arms, legs, fingers, and toes. Most affected infants die during the first several weeks of life, although longer-term survivors have been reported.
Description
Harlequin fetus represents the most severe presentation of inherited ichthyosis. The word ichthyosis, which is derived from the Greek word for fish, is a descriptive term used for a group of inherited disorders in which the skin is markedly thickened, ridged, and cracked....
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