Daclizumab
Definition
Daclizumab is a humanized monoclonal antibody of the IgG1 type produced by recombinant DNA technology that binds to a specific interleukin-2 (IL-2) receptor known as CD25 or Tac. This receptor is expressed on the surface of cancerous lymphocytes in a number of blood malignancies. Daclizumab has also been known as dacliximab and is marketed in the United States under the Zenapax brand name.
Purpose
When used against cancer, this drug is intended to stop the growth of blood cell (hematologic) cancers that express the CD25 protein on the surface of the cancerous cells. Some representative cancers include adult T-cell leukemia/lymphoma (ATL), hairy cell leukemia (HCL),
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